Supercritical Fluid Chromatography

Waters the Science of whats possible offers - SFC: A Greener Approach to Analytical and Purification Applications

For laboratories overwhelmed with solvent disposal and time-consuming solvent cleanup, supercritical fluid chromatography (SFC) is a beneficial alternative to purification and analytical applications. Considered a leading "green" purification technology, SFC systems from Waters are used to separate and isolate chiral and achiral chemical compounds using various methods of detection.

The principles of SFC are similar to those of liquid chromatography, however SFC typically uses carbon dioxide as the main mobile phase. SFC is essentially a normal-phase chromatographic technique with inherent high speed and efficiency due to its mobile phase. As a high pressure liquid, or supercritical fluid, using CO2 is a smart solvent for its low viscosity and high diffusivity needed in today's demanding purification labs and also a sustainable solvent as it is reused after being discarded from other industrial processes.

SFC excels at separating and purifying chiral compounds and natural products because it's faster, uses much less solvent, and overall is a less expensive and greener method that exceeds high pressure liquid chromatography (HPLC) in performance for chiral separations.

Whether you're just looking to analyze chiral compounds or need to purify those compounds, Waters has the solution that fits your needs.


Prep 15 SFC Purification System
The Waters Prep 15 SFC System is a powerful tool that provides high-throughput, semi-preparative purification and analytical screening.
Semi-Prep SFC Investigator


Investigator SFC System
The Investigator SFC System offers both analytical method development and semi-preparative purification. Once the optimal mobile phase and stationary phase are determined from screening, the method can be easily scaled for purification on the same system.


Prep 100q SFC System
Waters Prep 100q SFC System is the only preparative scale, open-bed supercritical fluid chromatography (SFC) system specifically designed for seamless, mass-triggered purification.
SFC Prep 80, 200, or 350


SFC 80q/200q and 350 Preparative Systems
Waters SFC 80, 200, and 350 Preparative systems for bulk-scale purification offer the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample.


ChromScope Software
ChromScope Software can be used with systems configured for method development and purification and is available with Waters Method Station and Investigator SFC Systems.

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