MALVA announces new collaboration with Xenocs    View More

MALVA took part at the Chem 2017 exhibition   See More

New Products

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. 

Single-use Harvesting Solutions for Research and Production up to 2,000 Liters

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities.

Inspired by the plasma industry, Sartoclear Dynamics® is based on the principles of body feed filtration. As a result, it replaces centrifuges and the subsequent depth filters in a single step.

Sartoclear Dynamics® Lab has been designed for simultaneous clarification and sterile filtration of small volumes of mammalian cell cultures produced in R&D labs. It saves valuable time and helps recover intact protein quickly and reproducibly for the next process step.

Sartoclear Dynamics® process solutions for ready-to-use clarification enable single-use processing of up to 2,000 liters mammalian cell culture. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology.

Depth Filters and Centrifuges vs. Sartoclear Dynamics®

In the past decade, the productivity of fed-batch mammalian cell cultures has risen significantly. Driven by optimized strains and culture media, biomass concentrations have increased from 1 – 3 g/l to 7 – 10 g/L.


Depth Filters and Centrifuges

High biomass concentrations challenge depth filters so that capacities have become very limited. Above 500 L a centrifuge seemed to be inevitable in order to reduce costs and waste.

With 2,000 L single-use bioreactors available a breakthrough technology was needed to enable a fully single-use process.

Our Clarification Solution up to 2,000 Liters

Sartoclear Dynamics® is a complete ready-to-use technology designed to harvest your bioreactor. Based on the principles of body feed filtration, it is ideal for high cell density cultures of up to 2,000 liters.

Our solution: The addition of a highly porous filter-aid to the feed stream. This increases the permeability of the filter cake and prevents the filter from getting blocked.

Your Benefits for Sartoclear Dynamics® Process Solutions

Save on an upfront investment in a centrifuge and its high maintenance costs. The single-use process of Sartoclear Dynamics® is fast, clean, reliable, economical and flexible.

The installation is quick and easy and preparation short since you do not have to preflush the filters. Sartoclear Dynamics® works with high flow rates and saves you the secondary step of depth filtration.

Do not worry about changing the volume of your bioreactor. You can adapt the amount of DE and the number of Sartoclear Dynamics® filtration units to whatever volume and size you may need.

With Sartoclear Dynamics® Scale you can easily determine the optimal ratio of DE to your biomass and linearly scale this to your process application.

Thanks to a constant ratio of diatomaceous earth (DE) to your biomass, the performance of Sartoclear Dynamics® is predictable. Variable parameters such as cell viability and cell size do not impact your results.

Sartoclear Dynamics® Lab

Sartoclear Dynamics® Lab products have been designed for harvesting small volumes of cell cultures in the labs. It performs the clarification and sterile filtration at a glance, fast, effortless, without any prior centrifugation step. The kits combine the use of a filter aid for clarification and a 0.2 µm filter for sterile filtration.

Sartoclear Dynamics® Scale

Sartoclear Dynamics® Scale is designed for determining the optimal process conditions for body feed based harvesting processes. The excellent scalability characteristics of the small scale device allows linear scaling with the process scale Sartoclear Dynamics® Filters.

Latest News

MALVA & Oxford Instruments

10 November 2022
MALVA & Oxford Instruments

MALVA Oxford Instruments Announce Collaboration Malva S.A. and Oxford Instruments have entered into an agreement to market the Atomic Force Microscopy, RAMAN Microscopy and Nuclear Magnetic Resonance product lines....


08 November 2022

    FOR IMMEDIATE RELEASE:     MALVA XENOCS ANNOUNCE COLLABORATION   Malva S.A.  and Xenocs jointly announce that they have entered into an agreement to collaborate for the market in...

LCMS Training Course

26 February 2021


LabGard® ES AIR NU-543E Class II Microbiological Safety Cabinet (2)

19 October 2018
 LabGard® ES AIR NU-543E Class II Microbiological Safety Cabinet (2)

The LabGard® ES (Energy Saver) AIR NU-543E is a bench top model with base stand options. Model NU-543E holds TUV and NSF listings meeting industry standards EN 12469 and NSF/ASNI...

TA Instruments Introduces a New Discovery SDT System

05 July 2017
TA Instruments Introduces a New Discovery SDT System

The Discovery SDT 650 delivers unprecedented performance in sensitivity, baseline stability, temperature and atmosphere control.

TA Instruments Introduces Three New Dilatometer Lines

04 July 2017
TA Instruments Introduces Three New Dilatometer Lines

TA Instruments is pleased to introduce three new Dilatometer product lines to the successful 800 platform:

New Calorimeter from TA Instruments

04 July 2017
New Calorimeter from TA Instruments

TA Instruments announces the introduction of the all new TAM Air Microcalorimeter.

Promotion 2016 Malva

30 September 2016
Promotion 2016 Malva

Until 31-12-2016. Take advantage of our 3 promotional packs.  

Sartorius Lab Seminar

04 November 2014
Sartorius Lab Seminar

Lab filtration – filter materials, typical applications, customer needs. Products of colony count – filters, Nutrient, Pad set (NPS), vacuum filtration systems

Malva Among Strongest Companies in Greece

01 November 2010
Malva Among Strongest Companies in Greece

Following the recent (2010) rating of 1A3 by D B, Malva S.A. is proud to announce that it is now recognized as one of the Strongest Companies in Greece


Our Partners

  • 1
  • 2
  • 3
  • 4
  • 5

Product Categories

About Us

Malva continuously strives to maintain leadership in all aspects of its analytical solutions portfolio

Stay Connected on:


Contact us

Please feel free to contact us at:

 This email address is being protected from spambots. You need JavaScript enabled to view it.
(+30) 210-8000904
(+30) 210-8001424
Athens: 13 Ilission, Ν. Kifissia 14564
Thessaloniki: 26 D. Glinou, 54249